downer

n (sl 俚) 1 drug having a depressant effect, esp a barbiturate 抑制药, 镇静药（尤指巴比妥类）. Cf 参看 upper n 2. 2 depressing experience, person, etc 令人沮丧的经历、 人等: What a downer that guy is! 那家伙多让人泄气呀!

douse (also dowse), dove, dovecote, Dover, dovetail, dowager, dowdily, dowdiness, dowdy, dowel, down, down draught (US down draft), down with, Down's syndrome, down-and-out, down-hearted, down-market, down-to-earth, downbeat, downcast, downfall, downgrade, downhill, Downing Street, download, downplay, downpour, downright, downs, downstairs, downstream, downtown, downtrodden, downward, downward(s), downwards, downwards (also downward), downy, dowry, dowse,